A genomic approach to unlocking the secrets of sarcoma

Principal Investigators: 
Institution: 

University of Birmingham 

Award Amount: 
£249,584
Duration: 
24 months

Leveraging single cell & long read sequencing to unlock the molecular heterogeneity and immunogenome of sarcomas.

There are still so few effective treatments for sarcoma, and many patients have to undergo life changing surgery as their best treatment option. This means there is a pressing need to discover new targets for drugs that could help people with sarcoma.

Targeting cancer cells while they are vulnerable to breakage

Principal Investigators: 

Professor Anderson Ryan 

Institution: 

The University of Oxford 

Award Amount: 
£116,545
Duration: 
42

Cancer cells grow in an uncontrolled manner, dividing and growing without fully duplicating their genetic material. This leaves them vulnerable to breakage in a way that normal cell are not. This PhD project is looking at ways to exploit this vulnerability in osteosarcoma cells, by using drugs that increase the instability in these cancer cells and cause them to die.

Managing the fear of sarcoma returning

Principal Investigators: 

Dr Rachel Taylor 

Institution: 

University College London Hospitals NHS Foundation Trust

Award Amount: 
£80,389
Duration: 
15 months

A person’s fear of their sarcoma returning can have a huge impact on their quality of life. This project will explore the nature of fear of recurrence in patients with sarcoma, leading to the development of an intervention to help patients manage this difficult issue.

The project builds on previous work by the same research group, also funded by Sarcoma UK.

Focusing high intensity ultrasound on sarcoma

Principal Investigators: 

Dr Paul Lyon

Institution: 

The University of Oxford

Award Amount: 
£119,934
Duration: 
48 months

High Intensity Focused Ultrasound is an exciting treatment method, capable of destroying a tumour by targeting it with focused ultrasound waves from outside the body. It is both non-invasive and uses no radiation. This exciting early phase study is looking at how High Intensity Focused Ultrasound can be applied to soft tissue sarcoma.

Investigating drug resistance in Alveolar Soft Part Sarcoma

Principal Investigators: 

Dr Robin Jones

Institution: 

The Institute of Cancer Research

Award Amount: 
£120,000
Duration: 
42 months

Sarcoma UK is investing in research leaders of the future. Our PhD programme aims to start a researcher’s career in sarcoma by funding a training fellowship which focuses on a hypothesis-driven research project.

Developing new drugs for sarcoma

Principal Investigators: 

Dr David Mann

Institution: 

Imperial College London

Award Amount: 
£119,873
Duration: 
42 months

Sarcoma UK is investing in research leaders of the future. Our PhD programme aims to start a researcher’s career in sarcoma by funding a training fellowship which focuses on a hypothesis-driven research project.

This exciting PhD project builds on preliminary work by this team identifying fragments of drugs which prevent cancer growth. These pieces will now be developed into chemicals that will form the basis of new drugs for the treatment of sarcoma.

Targeting a cancer ‘supercontroller’ in Ewing’s Sarcoma

Principal Investigators: 

Professor Susan Burchill

Institution: 

University of Leeds

Award Amount: 
£116,374
Duration: 
40 months

Sarcoma UK is investing in research leaders of the future. Our PhD programme aims to start a researcher’s career in sarcoma by funding a training fellowship which focuses on a hypothesis-driven research project.

This PhD project is investigating ways to turn off a protein called c-MYC which drives cancer progression in Ewing’s Sarcoma. The data from this research will provide important groundwork for the development of future treatment options.

Using MRI for response assessment of soft-tissue sarcoma to pre-operative radiotherapy.

Principal Investigators: 

Dr Matthew Blackledge

Award Amount: 
£24,490
Duration: 
36 months

This study will develop a new way to see how Soft Tissue Sarcoma is responding to Radiotherapy treatment. The project will look at spatial maps made and look at how different areas of the tumour are responding to treatment. It has the potential to improve patient outcomes, reduce treatment and fewer side effects for patients.

Using national cancer data to improve outcomes for sarcoma

Principal Investigators: 
Institution: 
Award Amount: 
£118,791
Duration: 
24 months

This project aims to better understand sarcoma care in England using cancer data. It will look at the most disadvantaged groups of patients and will scrutinise data to see what questions need to be answered to improve services and treatments for patients. It will improve care for patients using solid evidence basis.

The diagnostic experience of sarcoma patients

Principal Investigators: 
Institution: 

University College London Hospitals NHS Foundation Trust

Award Amount: 
£23,464
Duration: 
6 months

This project will look at information collected in the SPROM / SAM project to look at how patients first noticed symptoms that turned out to be sarcoma. It will look at what made them go to the doctor about the symptoms. It will ask what the doctors response was, and what factors may have affected the length of time to diagnosis.

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