Using MRI for response assessment of soft-tissue sarcoma to pre-operative radiotherapy.

Principal Investigators: 

Dr Matthew Blackledge

Award Amount: 
£24,490
Duration: 
36 months

This study will develop a new way to see how Soft Tissue Sarcoma is responding to Radiotherapy treatment. The project will look at spatial maps made and look at how different areas of the tumour are responding to treatment. It has the potential to improve patient outcomes, reduce treatment and fewer side effects for patients.

Using national cancer data to improve outcomes for sarcoma

Principal Investigators: 
Institution: 
Award Amount: 
£118,791
Duration: 
24 months

This project aims to better understand sarcoma care in England using cancer data. It will look at the most disadvantaged groups of patients and will scrutinise data to see what questions need to be answered to improve services and treatments for patients. It will improve care for patients using solid evidence basis.

The diagnostic experience of sarcoma patients

Principal Investigators: 
Institution: 

University College London Hospitals NHS Foundation Trust

Award Amount: 
£23,464
Duration: 
6 months

This project will look at information collected in the SPROM / SAM project to look at how patients first noticed symptoms that turned out to be sarcoma. It will look at what made them go to the doctor about the symptoms. It will ask what the doctors response was, and what factors may have affected the length of time to diagnosis.

GeCIPing Sarcoma: A UK-led initiative to personalise sarcoma treatment

Principal Investigators: 

Adrienne Flanagan

Institution: 

University College London

Award Amount: 
£250,000
Duration: 
36 months

A cancer-killing bone replacement wonder-material

Principal Investigators: 
Institution: 
Award Amount: 
£118,917.50
Duration: 
42 months

Sarcoma UK is investing in research leaders of the future. Our PhD programme aims to start a researcher’s career in sarcoma by funding a training fellowship which focuses on a hypothesis-driven research project.

This project is building on previous work, developing a bone replacement material which specifically kills cancer cells, actively encourages the growth of new bone cells and contains an antibacterial agent which reduces the possibility of surgical site infection.

Understanding resistance to chemotherapy

Principal Investigators: 
Institution: 
Award Amount: 
£120,000
Duration: 
42 months

Sarcoma UK is investing in research leaders of the future. Our PhD programme aims to start a researcher’s career in sarcoma by funding a training fellowship which focuses on a hypothesis-driven research project.

This project is looking to unpick the cellular processes and behaviours which determine if a person will respond to chemotherapy. How cells signal to each other is thought to affect how they respond to treatment. Understanding these processes will allow clinicians to personalise medicine by identifying the patients who will respond to chemotherapy before treatment has started. If the patient is unlikely to respond, another drug may be considered or the patient can be spared the side effects of chemotherapy.

Capturing the sarcoma cells that got away

Principal Investigators: 
Institution: 

University of Southampton

Award Amount: 
£24,820

This project uses new cutting edge techniques to compare rhabdomyosarcoma cells which do and don’t respond to chemotherapy. By understanding how some cells resist chemotherapy, we can work towards making them responsive to treatment.   

Tracing Sarcoma’s footprints

Principal Investigators: 
Institution: 

University College London

Award Amount: 
£120,000

This PhD project will use new computational approaches to identify where sarcomas have made changes to a person’s DNA and left a footprint (or ‘mutation signature’). Once these footprints can be identified in DNA, they can be used to identify which patients will respond to specific treatment. It will train a researcher of the future in this cutting edge research field.

Identifying and stopping cancer’s little helpers

Principal Investigators: 
Institution: 

University of Sheffield

Award Amount: 
£24,677

One of the cell types found in a sarcoma tumour is a fibroblast. Fibroblasts are known to be very important in the growth and spread of other cancers, but much less is known about how they work in sarcoma. This project will investigate the role of fibroblasts in soft tissue sarcoma. The more we know about how fibroblasts affect the growth and spread of sarcoma, the better we can fight it.

Developing crucially needed treatments for advanced Kaposi’s sarcoma

Principal Investigators: 
Institution: 

Birkbeck College, University of London

Award Amount: 
£23,934

Kaposi's sarcoma is a cancer resulting from infection by the Kaposi's sarcoma-associated herpesvirus. There are no effective treatments for the advanced disease. This project is searching for potential new treatments by developing methods of blocking the damaging proteins produced by the virus.

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