Soft tissue sarcoma survival | Sarcoma UK
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Soft tissue sarcoma survival

Key findings:

  • Net survival for all soft tissue sarcomas was 85.8% at 1-year and 70.2% at 5-years.
  • For those coded as malignant (excluding intermediate behaviour), survival was 83.1% at 1-year and 65% at 5-years.
  • Vascular tumours have the poorest outcome with a 5-year survival of 39%.
  • Patients diagnosed with GIST have a 5-year survival of 86%.
  • The 5-year net survival is slightly higher in males (68% vs 62%). This is due to a higher incidence of subtypes which are linked to poorer outcomes.

It’s worth noting that for some of the more rare subtypes of soft tissue sarcoma, the numbers were too low to calculate accurate survival statistics.

You can explore more of the findings in the figure and table below, or access the full paper here.

Figure 1: One- and five-year net survival according to morphological subtype and gender, for patients diagnosed between 2013 and 2017

Infographic detailing survival statistics for soft tissue sarcoma

Bacon, A., Wong, K., Fernando, M.S., Rous, B., Hill, R.J., Collins, S.D., Broggio, J. and Strauss, S.J., 2023. Incidence and survival of soft tissue sarcoma in England between 2013 and 2017, an analysis from the National Cancer Registration and Analysis Service. International Journal of Cancer152(9), pp.1789-1803.

 

Table 1: One- and five-year net survival according to morphological subtype and gender, for patients diagnosed between 2013 and 2017

Tumour Type N 1-year net survival LCI UCI 5-year net survival LCI UCI
Gastrointestinal stromal tumour
Gastrointestinal stromal tumours (intermediate behaviour) 2746 0.97 0.96 0.98 0.92 0.89 0.95
Gastrointestinal stromal tumours (malignant) 1173 0.93 0.91 0.95 0.75 0.69 0.8
Leiomyosarcoma
Epithelioid leiomyosarcoma 59 0.83 0.7 0.91
Leiomyosarcoma, NOS 2507 0.83 0.81 0.85 0.56 0.52 0.59
Undifferentiated sarcoma
Undifferentiated pleomorphic sarcoma 1094 0.82 0.8 0.85 0.58 0.52 0.65
Fibrous histiocytoma malignant 227 0.84 0.78 0.89 0.71 0.61 0.79
Spindle cell sarcoma 851 0.75 0.71 0.78 0.5 0.44 0.56
Undifferentiated sarcoma 276 0.59 0.53 0.65 0.44 0.36 0.53
Liposarcoma
Dedifferentiated liposarcoma 528 0.8 0.76 0.83 0.66 0.58 0.73
Liposarcoma, NOS; fibroliposarcoma 565 0.9 0.87 0.93 0.84 0.8 0.88
Liposarcoma well differentiated 544 0.99 0.97 1 0.96 0.92 0.99
Myxoid liposarcoma myxoliposarcoma 357 0.97 0.94 0.98 0.9 0.84 0.95
Pleomorphic liposarcoma 230 0.85 0.79 0.89 0.56 0.44 0.67
Other malignant soft tissue tumours
Adenosarcoma 225 0.88 0.82 0.92 0.77 0.68 0.85
Chondrosarcoma 114 0.9 0.82 0.95 0.79 0.66 0.89
Osteosarcoma, NOS 46 0.62 0.46 0.75
Sarcoma, NOS 1367 0.64 0.61 0.66 0.51 0.47 0.55
Myxoid and other fibroblastic tumours
Low-grade fibromyxoid sarcoma 75 0.92 0.81 0.97 0.83 0.64 0.94
Myxofibrosarcoma 875 0.95 0.93 0.96 0.79 0.73 0.85
Soft tissue tumours of intermediate behaviour
Abdominal fibromatosis 137 0.94 0.88 0.98 0.89 0.78 0.95
Atypical lipomatous tumours 512 1 0.98 1.01 1 0.94 1.03
Giant cell tumour of soft parts 114 1.01 1.01 1.01 1.04 0.92 1.05
Glomangiomatosis pericytic tumours 12 1.01 1.01 1.01
Haemangioendothelioma, NOS 17 1.01 1.01 1.01
Vascular tumours
Angiomyosarcoma 38 0.69 0.5 0.82
Epithelioid haemangioendothelioma malignant 67 0.84 0.72 0.92 0.77 0.62 0.87
Haemangiosarcoma angiosarcoma of soft tissue 800 0.62 0.58 0.65 0.32 0.27 0.37
Dermatofibrosarcoma protuberans
Fibrosarcomatous dermatofibrosarcoma protuberans 704 0.99 0.97 1 1 0.97 1.03
Tumours of uncertain differentiation
Clear cell sarcoma except of kidney m89643 35 0.88 0.71 0.96
Desmoplastic small round cell tumour 48 0.45 0.31 0.59
Epithelioid sarcoma 92 0.7 0.58 0.79 0.45 0.3 0.6
Myoepithelial carcinoma 64 0.92 0.81 0.98
Myxoid chondrosarcoma 68 0.96 0.86 1 1.01 0.9 1.06
Synovial
Synovial sarcoma biphasic 47 0.73 0.56 0.85
Synovial sarcoma, NOS 263 0.77 0.71 0.82 0.49 0.38 0.59
Synovial sarcoma spindle cell 63 0.77 0.63 0.86 0.51 0.35 0.65
Endometrial stromal tumour
Endometrial stromal sarcoma 238 0.77 0.7 0.82 0.57 0.48 0.64
Endometrial stromal sarcoma, low grade 151 0.98 0.93 1 0.93 0.82 0.99
Myofibrosarcomas and other fibroblastic sarcomas
Fibrosarcoma, NOS 54 0.92 0.8 0.97
Inflammatory myofibroblastic tumour 72 0.9 0.79 0.96 0.81 0.66 0.9
Malignant tenosynovial giant cell tumour 18 1.01 1.01 1.01 1.03 1.03 1.03
Solitary fibrous tumour, NOS 188 0.9 0.84 0.94 0.63 0.48 0.76
Malignant peripheral nerve sheath tumour
Malignant peripheral nerve sheath tumour, NOS 236 0.74 0.68 0.8 0.4 0.27 0.54
Malignant schwannoma neurilemoma malignant 54 0.9 0.78 0.96 0.85 0.68 0.94

1 and 5-year net survival for patients diagnosed between 2013 and 2017 by morphological subtype.

Net survival is estimated survival based only on deaths from the sarcoma in question and removes that from other causes (background mortality).

Net survival shown as a percentage of patients surviving to 1 and 5 years post diagnosis. This can be expressed as greater than 100% due to modifying behaviour after diagnosis which increases survival beyond expected.

Abbreviations: N – cohort size; LCI – Lower Confidence Interval; UCI – Upper Confidence Interval. Patients aged between 0-14 were excluded from analysis

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