International randomised controlled trial of chemotherapy for treatment of Recurrent and Primary Refractory Ewing Sarcoma
Age: 2 years old and above
Phase: 2
If you have Ewing sarcoma which cannot be removed by surgery or has returned after initial treatment, you may be given chemotherapy. This study originally compared four different chemotherapy treatments, but has since dropped three of the original treatments and has added an additional two chemotherapy treatments to compare. Therefore, this study now compares three different chemotherapy treatments:
carboplatin and etoposide (CE)
high-dose ifosfamide (IFOS)
high dose ifosfamide and lenvatinib (IFOS-L)
The aim of the trial is to find out which treatment works best and which has the fewest side effects. IFOS has shown evidence that it is likely to be more effective at controlling the disease than Topotecan and Cyclophosphamide (TC), Irinotecan and Temozolomide (IT) and Gemcitabine and Docetaxel (GD), which were previous chemotherapy regimens in this trial. Carboplatin and Etoposide (CE) and high dose Ifosfamide and Lenvatinib (IFOS-L) have been added to the study, to compare against high dose ifosfamide (IFOS).
More information can be found at cancerresearchuk.org
To find out more about this trial and whether you could take part, talk to your clinical team.
Locations:
London
- Royal Marsden Hospital London
- University College London Hospital
- Royal Marsden Hospital Sutton
North West
- Alder Hey Children’s Hospital, Liverpool
- Clatterbridge Cancer Centre, Wirral
- Christie Hospital, Manchester
- Royal Manchester Children’s Hospital
North East
- Royal Victoria Infirmary, Newcastle upon Tyne
- Freeman Hospital, Newcastle upon Tyne
South West
- Bristol Royal Hospital for Children
- Bristol Haematology and Oncology Centre
Yorkshire and Humberside
- St James’s University Hospital, Leeds
- Leeds General Infirmary
- Sheffield Children’s Hospital
- Weston Park Hospital, Sheffield
South East
- Churchill Hospital, Oxford
- John Radcliffe Hospital, Oxford
- Southampton General Hospital
West Midlands
- Queen Elizabeth Hospital, Birmingham
- Birmingham Children’s Hospital
East Midlands
- Queen’s Medical Centre, Nottingham
- Nottingham City Hospital
- Leicester Royal Infirmary
East Anglia
- Addenbrooke’s Hospital, Cambridge
Northern Ireland
- Royal Belfast Hospital for Sick Children
Scotland
- Royal Aberdeen Children’s Hospital
- Royal Hospital for Children and Young People, Edinburgh
- Royal Hospital for Children, Glasgow
- Beatson West of Scotland Cancer Centre, Glasgow
Wales
- Noah’s Ark Children’s Hospital for Wales
