Full title: Predicting Radiotherapy Response and Toxicities in Soft Tissue Sarcoma of the Extremities – Cohort B (PredicT-B)
Cambridge – Addenbrooke’s Hospital
London – Royal Marsden Hospital, University College London
This is a multicentre prospective cohort study, primarily aimed at reporting the frequency and intensity of radiotherapy side-effects of patients with soft tissues sarcoma of the extremities (STSE).
Two sub-studies are proposed within this study:
- MRI radiation response assessment Aimed at establishing whether changes in median apparent diffusion coefficients (ADC) are predictive of pre-operative STSE response measured using histopathology.
- Biomarker development and Immune mediators associated with radiotherapy Aimed at establishing prognostic markers which may refine selection of cases for pre-operative, palliative or no radiotherapy.
Also, aimed at determining if radiotherapy stimulates the tumour microenvironment, resulting in measurable change in anti-tumour immunity and if certain subtypes could potentially benefit from the addition of immunotherapy with radiation.
Patients participation in the sub-studies is optional.
More information can be found at clinicaltrials.gov
To find out more about this trial and whether you could take part, talk to your clinical team.