Professor Brennan is a Consultant Paediatric Oncologist at the Royal Manchester Children’s Hospital, with over 30 years’ experience as a qualified doctor, as well as further training in General Paediatrics, Paediatric and Adolescent Oncology and an MD in the late effects of Childhood Leukaemia.

She focuses on Ewing sarcoma, osteosarcoma, paediatric soft tissue sarcomas and rare paediatric tumours. She is national coordinator for the non-rhabdomyosarcoma soft tissue sarcomas study (NRSTS) run by the European Paediatric Soft tissue sarcoma Study Group (EPSSG) and chair of the NCRI Sarcoma Group. She is an active member of the Euro Ewing Consortium including as a chief investigator of the UK Euro Ewing 2012 Study, principal investigator for rEECur and chief investigator of the INTER-EWING-1 trial.

She is also a member of the Children’s Cancer and Leukaemia Group (CCLG), the CCLG Rare Tumour Group and the EXPeRT European Rare Tumour Group