Institution: University of Sheffield
Project title: Studies in angiosarcoma using canine tumours
Researcher: Dr Robin Young
Grant award: £17,500
Duration: 2012 – 2014
In humans angiosarcomas are rare, aggressive tumours of blood vessels. Angiogenesis is the process of new blood vessel formation and is controlled by a number of different growth factors. The researchers think it is likely that these growth factors are important in the development of angiosarcoma, and that treatments targeting these factors will be useful for patients with angiosarcoma. Whilst human angiosarcoma is rare the tumour is much more common in dogs and it will be seen by vets in their surgeries when your GP will never see a case. This means that samples of tumour from dogs are available for study, potentially to the advantage of dogs and people. Doing this will promote better understanding of angiosarcoma in humans and in dogs. As angiogenesis is important in the growth of other sarcomas these studies will also be relevant to the treatment of other sarcoma sub-types. It is expected that results from these studies will lead to clinical trials in both humans and dogs, thereby helping improve the treatment of angiosarcoma in both.