Principal Investigators: 

Professor Valerie Brunton 

Institution: 

The University of Edinburgh

Award Amount: 
£199,188
Duration: 
42 months

Undifferentiated pleomorphic sarcoma (UPS) is the most common subtype of soft tissue sarcoma. However, these cancers vary a great deal from person to person and are genetically very complex, meaning that there are very few new treatment options, and no important advances have been made in recent years.

Professor Brunton’s team have set up a screen to test which drugs may be able to stop the growth of and/or kill UPS cells. In this PhD project, the screen will be extended to look at activity of a further set of known anti-cancer drugs.

The student will then test these drugs in further laboratory models of UPS, which aim to better reflect how tumours behave in patients. The student will analyse changes in gene activity and protein expression, as well as the environment around the tumour cells.

Developing new treatments for sarcoma relies on having good models of cancer that can studied in the laboratory. This PhD studentship project aims develop better models of undifferentiated pleomorphic sarcoma and to test potential drugs in these models, bringing us closer to making effective treatments available.

Project status: 
open