This project investigates how the internal pressure of osteosarcoma tumours effects the growth and spread of the tumour. By gaining a better understanding of the role of internal pressure in osteosarcoma, it can be harnessed and targeted in treatments.
Sarcoma fuelled by the squeeze – Does the Hippo release the pressure?
Osteosarcoma tumours are affected by a variety of factors. One is the internal pressure of tumours, which is generally higher than the surrounding healthy tissue. This increased pressure is known to have an effect on drugs reaching the tumour. The increased pressure is also known to promote tumour growth and increases the risk of the tumour spreading.
This project looks at how this pressure is generated in osteosarcoma, how osteosarcoma cells respond to different pressures and what causes sarcoma cells with high internal pressure to grow and spread.
Targeting osteosarcoma’s higher internal pressure may lead to better treatment for osteosarcoma patients.