Professor Janet Shipley, Dr Anastasia Constantinidou
Liposarcomas are a type of soft tissue sarcoma that arises in fat cells. Well-differentiated (WD) liposarcomas have clear cell walls and a regular appearence under the microscope. De-differentiated (DD) liposarcomas are much messier and irregular. Both are the most frequent subtype of liposarcomas in adults. Well-differentiated liposarcomas can recur looking more like the de-differentiated type. This is associated with increased aggressiveness. In contrast, completely well-differentiated liposarcomas are usually readily curable. This project aims to identify the genes involved in making de-differentiated liposarcomas behave more aggressively, so that new therapies can be developed to target these genes and hopefully result in less aggressive liposarcomas.
Presentations & Workshops
- Constantinidou, J. et al. Epigenetic modulation in well differentiated (WD) and dedifferentiated (DD) liposarcoma (LPS): a novel therapeutic approach. Presentation given European Society for Medical Oncology (ESMO). October, 2016. Copenhagen, Denmark.
- This work contributed to Dr Anastasia Constantinidou’s 2015 PhD Thesis entitled: Identification of Genes Involved in the Differentiation of Liposarcomas as Novel Targets.