Professor Janet Shipley, Dr Anastasia Constantinidou
Liposarcomas are a type of soft tissue sarcoma that arises in fat cells. Well-differentiated (WD) liposarcomas have clear cell walls and a regular appearence under the microscope. De-differentiated (DD) liposarcomas are much messier and irregular. Both are the most frequent subtype of liposarcomas in adults. Well-differentiated liposarcomas can recur looking more like the de-differentiated type. This is associated with increased aggressiveness. In contrast, completely well-differentiated liposarcomas are usually readily curable. This project aims to identify the genes involved in making de-differentiated liposarcomas behave more aggressively, so that new therapies can be developed to target these genes and hopefully result in less aggressive liposarcomas.
- A. Constantinidou A. et al. Epigenetic modulation in well differentiated (WD) and dedifferentiated (DD) liposarcoma (LPS): a novel therapeutic approach. ESMO meeting Copenhagen, Denmark 2016. Published in Annals of Oncology. 11th October 2016. Volume 27. Alongside a poster discussion presentation during the ESMO 2016 Congress, 7-11 October, Copenhagen, Denmark.
- This work contributed to Dr. Anastasia Constantinidou 2015 PhD Thesis: Identification of Genes Involved in the Differentiation of Liposarcomas as Novel Therapeutic Targets.