Myxofibrosarcomas are cancers that most commonly develop in the limbs. Surgery is the main treatment but because of the way these cancers grow, it is a challenge to successfully remove them. Unlike other cancers that are easily visible to the surgeon, myxofibrosarcomas often infiltrate nearby tissues making it difficult to accurately assess how much cancer is present. There is a risk that some cancer is left behind after surgery, and this may result in a poorer outcome for the patient.
To make the most of the information we have when planning surgery, patients are routinely scanned using MRI (Magnetic Resonance Imaging) to give us information about the cancer. Myxofibrosarcomas are often invisible and difficult to distinguish from normal tissue. However, another type of scan, called PET (Positron Emission Tomography) can identify other types of cancer in a different way. PET identifies the function of the cancer instead of the appearance of the cancer. We believe that by using PET and new MRI techniques, we will be able to better assess myxofibrosarcomas, potentially leading to more successful surgery and a better outcome for the patient.
We will compare PET-MRI with PET and MRI alone in a small group of patients with myxofibrosarcomas. This comparison will involve a single scan on a PET-MRI camera that allows the PET and MRI to be taken at the same time. PET scans use a small amount of radiation, but we believe the potential benefits of PET outweigh any risks.