Soft tissue sarcomas can be removed by surgery, but may return. All cancers are different which affects how they respond to treatment. A test is needed to predict which tumours will return and what treatments will prevent this.
Low oxygen levels in cancer, called hypoxia, make them harder to treat. Research has identified a gene signature to measure hypoxia in sarcomas. The signature needs testing in cells in a laboratory to make sure the signature is definitely measuring hypoxia in soft tissue sarcoma.
This project aims to find out which genes are expressed when sarcoma cells are hypoxic and use the information to measure hypoxia. The project will also use the gene expression data to identify which drugs kill hypoxic sarcoma cells.
The project will test seven sarcoma cell lines grown in high and low oxygen, with the results used to improve the gene signature test. The research will find out whether the signature predicts how patients respond to treatment. The gene signature data can also be studied to find potential drug targets for hypoxic sarcoma cells.
This research has the potential to identify patients who would benefit from treatment targeting hypoxia to improve their outcome in soft tissue sarcoma.