Ewing's sarcoma is a highly aggressive bone tumour which predominantly affects children, adolescents and young adults. It is a tumour that causes extensive bone destruction and can spread rapidly. The bone destruction in Ewing’s is caused by osteoclasts, specialised bone cells which normally breakdown bone in balance with osteoblasts which build it up This study aims to look more closely at the way Ewing’s cells promote osteoclast formation which then knocks normal bone biology out of kilter, increasing bone destruction. This study may then open up a new avenue of additional treatment of Ewings and other bone sarcomas such as osteosarcoma. Sarcoma UK is funding the equipment needed for this study.
- Presentation on Epi Genetics in Sarcoma at the Brain Tumour Research Campaign Meeting, Bristol 2013