Type of sarcoma: 
Oxford, London, Cardiff, Sutton, Newcastle, Leicester

Full title: A Phase 1/2 Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Gemcitabine plus Cisplatin or Gemcitabine Alone in Subjects with Advanced Cancer

Age: 18+
Phase: 2

If you have a soft tissue sarcoma that has spread to another part of your body or if it can’t be removed through surgery you may be treated with chemotherapy. Chemotherapy drugs are sometimes given on their own or as combinations to try to help control your symptoms and prevent the tumour from growing. This trial is for patients whose sarcoma has got worse despite being treated with chemotherapy.

This trial is looking at how safe and effective a new drug (SRA737) is and how well it works when combined with a low dose of the drug gemcitabine to treat different types of cancers including sarcoma. Gemcitabine is already used in the treatment of sarcoma and works by interfering with processes in cancer cells preventing them from multiplying and growing. SRA737 blocks the tumour cells ability to respond to DNA damage caused by chemotherapy and may make chemotherapy treatment more effective.